AutoNumber Vs Number

Question

Language: DataBase.

Program: Microsoft Access.

Question: When creating new tables. What is a good practice to use AutoNumber and what is a good practice to use Number? In other words, when is it better to use which? I know the differences but I am just not sure how that would effect implementation when using a programming language like C# to read/write in/to the database.

Feel free to go in as many details and view this in different angles if you like to. The more info I can get the better.

Thank you.
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