executing query builder sql

Dumb question but what's the best means of executing the result of my query builder? https://orm.drizzle.team/docs/goodies#standalone-query-builder

// what's the best way to execute this sql / parms?
const { sql, params } = query.toSQL();

// what's the best way to execute this sql / parms?
const { sql, params } = query.toSQL();

// what's the best way to execute this sql / parms?
const { sql, params } = query.toSQL();

// what's the best way to execute this sql / parms?
const { sql, params } = query.toSQL();