Leverge multi-tenency while deploy web application with user generated data

Posted a broader question to fully grasp on how can I built using Cloudflare Stack.

Requirements:
* Deploy a web application which will server the user generated content
* User can set custom domain to the web application

From what I understand:
* CF Worker can be used to accept all incoming requests from multiple custom domains to single worker by using
map URL pattern

* User generated data can be stored in D1
* KV can be used to map the custom domain ID to user generated content

How can I truly achieve a multi-tenency in the above scenario? Any/all help is really appreciated? 🙏
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