@Agung Vivekananda to add on to Matt's response, Hyperdrive will be able to connect to supabase's database directly (without the supabase connection pooler).
If you attempt to develop locally with your supabase database with npx wrangler devnpx wrangler dev, you may encounter errors in case your ISP does not support IPV6. If that is the case, consider using the npx wrangler dev --remotenpx wrangler dev --remote option.