@SirDigby {Mod Name} Got another one, chief.
I'm not even going to sugar coat this one with a big blurb and just get to the point.
Long story short, I was redoing some sorting in my factory to add some more space for solid biofuel. Went to delete an MLB filter module, and it immediately hung my game and wouldn't do anything until I manually closed it through task manager. Thought it might have been just a one-time thing, so I went to do it again after loading the save - and it hung the game, again.
It didn't hardcrash the game, mind - it just hung it where it was. No visual updates, audio was still playing, CPU and GPU cycles hit the floor.