Calibration cube tuning

Just finished printing the calibration cube. I'm amazed at the results, however I'd like to know what and how I should tune the printer/slicer now based on the cube. The threaded bolt screws in a couple turns, however is quite stiff so immediately I think Xy compensation would be required. There's some ugly overhangs as well, would fan speed or print speed fix that issue, or is it more temperature related?