Transparency and overriding

I'm curious, if we have 3 elements on top of each other,
lets say blue is the lowest (takes the full screen), orange is in the middle (also takes the full screen), and on the top is the square elememt (like 400x400px) that's transparent

Can we do anything do make the square area show blue isntead of the orange? Aka somehow make the middle layer transparent from the square? Like piercing transparency? If that makes any sense?

Otherwise if the box is transparent we will just see orange
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