Sudden first layer issues

Hi there, since a few weeks (i'm not printing on a regular basis right now) I get weird artifacts/salmon skin and/or irregular extrusion on my first layers. Today I tried to print a larger part, but stopped it during the brim. I'm not sure if those issues are extrusion related, or if it could be a mechanical issue - i suspect something in between because for me it looks like the extrusion - especially in X - is squiggly/wavey. On the other hand i've also seen similar patterns that where caused by a faulty extruder.

I'm using an Orbiter 1.5 and a Dragon SF on a V-Core 3.1 300. Today was the worst i've had yet, before the print i leveled the bed and recalibrated the z-offset at room temperature (tried a new bed plate). Before I proceed and take half of the printer apart, I thought why not ask if someone experienced something similar and could guide me in the right direction.
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