What I personally like to do with Bottles is create a new prefix for each game I'm trying to run, just so it's better organised. But you can also get away with just one general prefix too
You'll also likely need to add the directories you're running from to the sandbox. You can do this by downloading/running Flatseal, go to Bottles, and add your directory in the appropriate location:
Yeah that's all I used for the past couple years I modified it a bunch to be more console like but I never made it fully work seemlessly and ltsc was running out of support cause it was 21h2 lol
The Bottles sandbox is nice though, since you can be rest assured anything you're running in it can only affect folders and files that are specified in the sandbox