Cache obscenely slow, even after purges and disabling smart topology

We have a domain assets.tangia.co that is cached with CF, and over the last 2 weeks it has started griding to a halt. <1MB images take 20s+ to load from gigabit connections, and we've purged the cache many times.

It's directly hooked up to S3 so we know it's not the origin being slow
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