I've been having troubles for the past few weeks now (see 🎮bazzite), any time I attempt to update my Laptop (an ASUS TUF Gaming A16 FA617XS).
As soon as I attempt to login to KDE following an update, the system almost always hangs, with the loading wheel freezing, and the desktop never appearing, no matter how long I leave the system. On rare occasions, the system does actually login following an update, but while it swiftly move to the desktop in those instances, this is accompanied with continuous extreme graphical artifacts (similar to what was reported here - ASUS ROG G14: AMD Integrated GPU issues), which make the system basically impossible to use effectively.
I'm able to use the system for now by rolling back to the last known working image (bazzite-asus:stable-41.20250106.3), which doesn't suffer from of these issues. That's obviously not a long-term working solution though, so I'm hoping someone might be able to identify what it is in the images since this which could be causing the problem.