You can create multiple databases via the API and set a location hint: https://developers.cloudflare

You can create multiple databases via the API and set a location hint: https://developers.cloudflare.com/d1/configuration/data-location/#:~:text=Location%20hint%20is%20an%20optional,are%20creating%20the%20database%20from They are not automatically provisioned in different regions. They would have different data. D1 databases do not have replication yet, however that is something that is expected to come soon.
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