I am not actually that familiar with Rufus and currently do not have access to a Windows installation, or have hardware capable of running it in a VM. However I can recommend trying to flash the ISO again with Balena Etcher or Fedora Media Writer. Both have Windows ports.
I'm having an issue where I'm unable to play games in bazzite-gnome-nvidia using mouse and keyboard because the keyboard input gets delayed. I've noticed this in Helldivers 2, Rocket League, and Doom. Mouse input and controller input appear unaffected. I have tried a few different keyboards, and I haven't noticed this behavior anywhere else in the operating system, only in games. I made two videos demonstrating this where I hit a lot of keys to demonstrate. But it sometimes happens with much much less busy key input. It's as if for a while new key input is unable to be made while the old inputs are still being played out.
I googled similar issues and searched the discord. I made sure Sticky Keys and other Assistance features were not turned out, and activating them via the keyboard is also disabled.
Multiple mice seem unaffected, and I can't replicated any similar behavior at all with a lot more gamepad (xbox elite V2) inputs, they all seem to go perfectly live with no delay.