If we say F(x) = 2^n
From graph, as you mentioned the slope of secant, since the function 2^n is strictly increasing, the functional value will always be less than the average value of slope in the interval (0,2n+1).
What I mean to say is,
(F(2n+1) - F(0))/(2n+1-0) > F(x), where x belongs to (0,2n+1)
Therefore, 2^(2n+1) - 1/2n+1 > 2^n